Research Articles
Boosting Drug Success Rates: A 2024 Guide to PK/PD Target Attainment Analysis and Optimization
This comprehensive guide explores advanced strategies for improving Pharmacokinetic/Pharmacodynamic (PK/PD) target attainment rates in modern drug development.
Extending Therapeutic Lifespan: PEGylation Strategies to Overcome Antimicrobial Peptide (AMP) Half-Life Limitations
This article explores the critical application of PEGylation to enhance the circulating half-life of antimicrobial peptides (AMPs), a promising yet pharmaceutically challenging class of therapeutics.
PBPK vs. PopPK Modeling in Anti-Infective Development: Choosing the Right Pharmacokinetic Tool for Success
This article provides a comprehensive guide for drug development scientists on selecting and applying physiologically-based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) modeling in anti-infective development.
Predicting DDIs in Anti-Infective Therapy: A Comprehensive Guide to PBPK Modeling Strategies
Physiologically-Based Pharmacokinetic (PBPK) modeling has emerged as a critical tool for predicting and understanding Drug-Drug Interactions (DDIs) in anti-infective therapy.
Accelerating Anti-Infective Drug Development: A Comprehensive Guide to PBPK Modeling for Candidate Selection
This article provides a detailed guide for researchers and drug development professionals on applying Physiologically-Based Pharmacokinetic (PBPK) modeling to optimize anti-infective candidate selection.
Breaking the Wall: Strategies to Overcome GC Barriers in Pathogen Genetic Manipulation
This article provides a comprehensive analysis for researchers and drug development professionals on the challenges and solutions for genetic manipulation in high-GC content pathogens.
Advanced Strategies for Detecting Low-Frequency Antibiotic Resistance Gene Transfer: Methods and Validation
This article provides a comprehensive guide for researchers and drug development professionals on optimizing the detection of low-frequency antibiotic resistance gene (ARG) transfer.
Integrating Human, Animal, and Environmental Health: A One Health Framework for Combating Antimicrobial Resistance
This article provides a comprehensive analysis of the One Health approach as a critical framework for preventing and mitigating antimicrobial resistance (AMR).
Natural Transformation: The Hidden Engine of Antibiotic Resistance Spread in Bacterial Pathogens
This comprehensive review explores the critical role of natural transformation in driving the evolution and dissemination of antibiotic resistance among bacterial pathogens.
Natural Transformation Assays for ARG Uptake: Methods, Protocols, and Applications in Antimicrobial Resistance Research
This comprehensive guide explores natural transformation assays as critical tools for studying the horizontal gene transfer of antimicrobial resistance genes (ARGs).